IHC of CD75 on an FFPE Liver Tissue

IHC of CD75 on an FFPE Liver Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCD75, also known as CDw75 or Beta-galactoside alpha-2,6-sialyltransferase 1( ST6GAL-1) is an enzyme that in humans is encoded by the ST6GAL1 gene. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein, which is normally found in the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76.CD75 is a antibody which labels germinal centre B-cells as well as epithelial cells, however is absent in plasma cells. It reacts with RBC precursors of bone marrow, ductal and ciliated epithelial cells of kidney, breast, prostate, pancreas, lung, and with glioblastomas, astrocytomas, and Reed Sternberg cells in lymphocyte predominant Hodgkin’s disease. It is shown to be a helpful antibody for ascribing a B-cell phenotype in known lymphoid tissues.
Antibody TypeMouse MonoclonalCloneLN-1
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlLiver, Prostate, Kidney Tonsil
PresentationCD75 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, fi lter sterilized and diluted in buff er pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2719PredilutedReady-To-Use3.0 ml
BSB 2720PredilutedReady-To-Use7.0 ml
BSB 2721PredilutedReady-To-Use15.0 ml
BSB 2722Concentrated1:250-1:10000.1 ml
BSB 2723Concentrated1:250-1:10000.5 ml
BSB 2724Concentrated1:250-1:10001.0 ml
BSB 2725Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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