IHC of CD74 on an FFPE Tonsil Tissue

IHC of CD74 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

CD74, also known as the MHC Class II-associated invariant chain (II), is a Type II transmembrane protein which binds to the peptide-binding groove of newly-synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen-presenting cells such as B-lymphocytes (from before the pre-B-cell stage to before the plasma-cell stage), macrophages and monocytes, together with many epithelial cells. CD74 stains predominantly germinal-center lymphocytes and B-cell lymphomas but rarely T-cell lymphomas. It stains the cell membrane but a paranuclear globular labeling is also noted. CD74 is useful in differentiating Atypical Fibroxanthoma from Malignant Fibrous Histiocytoma, as well as Small-cell Lung Carcinoma from Non-small cell Lung Carcinomas.

Antibody TypeMouse MonoclonalCloneN2
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlTonsil, Lymph Node
PresentationCD74 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5295PredilutedReady-To-Use3.0 ml
BSB 5296PredilutedReady-To-Use7.0 ml
BSB 5297PredilutedReady-To-Use15.0 ml
BSB 5298Concentrated1:250-1:10000.1 ml
BSB 5299Concentrated1:250-1:10000.5 ml
BSB 5300Concentrated1:250-1:10001.0 ml
BSB 3301Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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