IHC of CD74 on an FFPE Tonsil Tissue

IHC of CD74 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

CD74, also known as the MHC Class II-associated invariant chain (II), is a Type II transmembrane protein which binds to the peptide-binding groove of newly-synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen-presenting cells such as B-lymphocytes (from before the pre-B-cell stage to before the plasma-cell stage), macrophages and monocytes, together with many epithelial cells. CD74 stains predominantly germinal-center lymphocytes and B-cell lymphomas but rarely T-cell lymphomas. It stains the cell membrane but a paranuclear globular labeling is also noted. CD74 is useful in differentiating Atypical Fibroxanthoma from Malignant Fibrous Histiocytoma, as well as Small-cell Lung Carcinoma from Non-small cell Lung Carcinomas.

Antibody Type Mouse Monoclonal Clone N2
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Tonsil, Lymph Node
Presentation CD74 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5295 Prediluted Ready-To-Use 3.0 ml
BSB 5296 Prediluted Ready-To-Use 7.0 ml
BSB 5297 Prediluted Ready-To-Use 15.0 ml
BSB 5298 Concentrated 1:250-1:1000 0.1 ml
BSB 5299 Concentrated 1:250-1:1000 0.5 ml
BSB 5300 Concentrated 1:250-1:1000 1.0 ml
BSB 3301 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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