IHC of CD7 on an FFPE Tonsil Tissue

IHC of CD7 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation CD7 is a 40 kDa transmembrane, single-chain glycoprotein, which is a member of the immunoglobulin gene superfamily. It is expressed in the majority of immature and mature T-lymphocytes, and T-cell Leukemia. It is also found in natural killer cells, a small subpopulation of normal B-cells and in malignant B-cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. CD7 is a consistently-expressed T-cell antigen in Lymphoblastic Lymphomas and Leukemias; therefore, it is a useful marker in the identification of such neoplastic proliferations. CD7 is expressed in the majority of mature peripheral T-cells, the majority of post-thymic T-cells, NK cells, some myeloid cells, T-cell Acute Lymphoblastic Leukemia/Lymphoma, Acute Myelogenous Leukemia and Chronic Myelogenous Leukemia. Interestingly, CD7 is conspicuously absent in adult T-cell Leukemia/Lymphoma and is not expressed in Sezary cells.
Antibody Type Mouse Monoclonal Clone LP15
Isotype IgG2b Reactivity Paraffin, Frozen
Localization Membranous Control Tonsil, Lymph Node
Presentation CD7 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5162 Prediluted Ready-To-Use 3.0 ml
BSB 5163 Prediluted Ready-To-Use 7.0 ml
BSB 5164 Prediluted Ready-To-Use 15.0 ml
BSB 5165 Concentrated 1:25-1:100 0.1 ml
BSB 5166 Concentrated 1:25-1:100 0.5 ml
BSB 5167 Concentrated 1:25-1:100 1.0 ml
BSB 5168 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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