HC of CD68 on an FFPE Tonsil Tissue

IHC of CD68 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.
Summary and Explanation The CD68 antigen is a heavily glycosylated trans-membrane protein of 87-115 kDa which is specifically expressed by tissue macrophages, Langerhans cells and, at low levels, by dendritic cells. CD68 could play a role in phagocytic activities of tissuemacrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions.CD68 marks cells of monocyte/macrophage lineage. This antibody is capable of staining monocytes, Kupffer cells, osteoclasts, granulocytes and their precursors; Lymphomas are negative or show a few granules. This antibody may be useful for the identification of Myelomonocytic and Histiocytic Tumors. CD68 may help to distinguish Malignant Fibrous Histiocytoma from other Pleomorphic Sarcomas.However, since CD68 detects a formalin-resistant epitope that may be associated with lysosomal granules, other lysosome-rich cells may also produce positive results.
Antibody Type Mouse Monoclonal Clone KP-1
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Tonsil, Lymph Node
Presentation CD68 is a mouse monoclonal antibody derived from cell culture supernatant that
is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing
BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2712 Prediluted Ready-To-Use 3.0 ml
BSB 2713 Prediluted Ready-To-Use 7.0 ml
BSB 2714 Prediluted Ready-To-Use 15.0 ml
BSB 2715 Concentrated 1:250-1:1000 0.1 ml
BSB 2716 Concentrated 1:250-1:1000 0.5 ml
BSB 2717 Concentrated 1:250-1:1000 1.0 ml
BSB 2718 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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