IHC of CD56 on an FFPE Neuroblastoma Tissue

IHC of CD56 on an FFPE Neuroblastoma Tissue

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Research Use
Safety Data Sheet
Intended Use For In Vitro Diagnostic Use
Summary and Explanation CD56 or Neural-Cell Adhesion Molecule (NCAM) is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. CD56 has been implicated in cell-cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory. Normal cells that stain positively for CD56 include NK cells, activated T-cells, brain and cerebellum, and neuroendocrine tissues. Tumors that are CD56-positive are Myeloma, Myeloid Leukemia, Neuroendocrine tumors, Wilm’s Tumor, Adult Neuroblastoma, NK/T cell Lymphomas, Pancreatic Acinar-cell Carcinoma, Pheochromocytoma, and Small-cell Lung Carcinoma. It is also expressed on some mesodermally-derived tumors (Rhabdomyosarcoma). Ewing’s Sarcoma/PNET is CD56-negative.
Antibody Type Mouse Monoclonal Clone 123C3.D5
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Membranous Control Pancreas, Tonsil, Neuroblastoma, Brain, Thyroid, Prostate, Colon, Lung SCC
Presentation CD56 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5267 Prediluted Ready-To-Use 3.0 ml
BSB 5268 Prediluted Ready-To-Use 7.0 ml
BSB 5269 Prediluted Ready-To-Use 15.0 ml
BSB 5270 Concentrated 1:250-1:1000 0.1 ml
BSB 5271 Concentrated 1:250-1:1000 0.5 ml
BSB 5272 Concentrated 1:250-1:1000 1.0 ml
BSB 5273 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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