IHC of CD45R on an FFPE Tonsil Tissue

IHC of CD45R on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation CD45R contains an extracellular domain, a single transmembrane segment and two tandem intracyto-plasmic catalytic domains. It is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T and B-cell antigen-receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen-receptor signaling. CD45R also suppresses JAK kinases, and thus functions as a regulator of cytokine-receptor signaling. CD45R represents a restricted form of the CD45 family, which primarily recognizes only cells of B lineage from proB-cell through mature B lymphocytes and, prior to the availability of anti-CD19 MAbs, was commonly used as a pan B-cell marker. It also reacts with certain activated T-cells, as well as non-MHC restricted lytically active lymphokine-activated killer (LAK) cells. MB1 antibody stains preferentially B-cells and their neoplasms but is less specific, as it will also react with some T-cell Lymphomas and Non-lymphoid Tumors. The antigen for this antibody is in the membrane of all B-cells with the exception of plasma cells and some mature T-cells.
Antibody Type Mouse Monoclonal Clone MB1
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Membranous Control Tonsil, Lymph Node
Presentation CD45R is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6254 Prediluted Ready-To-Use 3.0 ml
BSB 6255 Prediluted Ready-To-Use 7.0 ml
BSB 6256 Prediluted Ready-To-Use 15.0 ml
BSB 6257 Concentrated 1:25-1:100 0.1 ml
BSB 6258 Concentrated 1:25-1:100 0.5 ml
BSB 6259 Concentrated 1:25-1:100 1.0 ml
BSB 6260 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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