IHC of CD44 on an FFPE Breast Fibroadenoma Tissue

IHC of CD44 on an FFPE Breast Fibroadenoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.
Summary and Explanation The CD44 protein is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. CD44 is also known as Homing-cell adhesion molecule (H-CAM) and Phagocytic glycoprotein-1 (PgP-1). A specialized sialofucosylated glycoform of CD44 called HCELL is found natively on human hematopoietic stem cells and functions as a “bone-homing receptor”, directing migration of human hematopoietic stem cells and mesenchymal stem cells to bone marrow. This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms; however, the full-length nature of some of these variants has not been determined. Splice variants of CD44 on Colon Cancer cells display the HCELL glycoform, which mediates binding to vascular E-selectin under hemodynamic flow conditions, a critical step in Colon Cancer metastasis. In addition, variations in CD44 are reported as cell surface markers for some breast and prostate cancer stem cells and have been seen as an indicator of increased survival time in Epithelial Ovarian Cancer patients.
Antibody Type Mouse Monoclonal Clone BSB-12
Isotype IgG2a Reactivity Paraffin, Frozen
Localization Membranous Control Urothelium, Tonsil, Kidney, Breast, Liver, Skin, Prostate, Thymus, Spleen, Lymph Node, Esophageal Carcinoma
Presentation CD44 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6233 Prediluted Ready-To-Use 3.0 ml
BSB 6234 Prediluted Ready-To-Use 7.0 ml
BSB 6235 Prediluted Ready-To-Use 15.0 ml
BSB 6236 Concentrated 1:250-1:1000 0.1 ml
BSB 6237 Concentrated 1:250-1:1000 0.5 ml
BSB 6238 Concentrated 1:250-1:1000 1.0 ml
BSB 6239 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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