IHC of CD43 on an FFPE Tonsil Tissue

IHC of CD43 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.
Summary and Explanation CD43 (leukosialin, sialophorin, or leukocyte sialoglycoprotein) is one of the major glycoproteins expressed in all thymocytes and T-cells. It plays a role in the physicochemical properties of the T-cell surface and in lectin binding. During T-cell activation, CD43 is actively removed from the T-cell antigen-presenting cell contact site, suggesting a negative regulatory role in adaptive immune response. This antibody has been found useful in identification and classification of T-cell malignancies and low grade B-cell Lymphomas. CD43 expression is seen in some cases of B-cell Lymphocytic Lymphoma and Centrocytic Lymphoma. When used in combination with CD45 and CD20, effective immunophenotyping of the majority of Lymphomas can be obtained. Co-staining of a lymphoid infiltrate with CD20 and CD3 argues against a reactive process and favors Lymphoma.
Antibody Type Mouse Monoclonal Clone MT1
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Membranous Control Tonsil, Lymph Node
Presentation CD43 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5239 Prediluted Ready-To-Use 3.0 ml
BSB 5240 Prediluted Ready-To-Use 7.0 ml
BSB 5241 Prediluted Ready-To-Use 15.0 ml
BSB 5242 Concentrated 1:100-1:500 0.1 ml
BSB 5243 Concentrated 1:100-1:500 0.5 ml
BSB 5244 Concentrated 1:100-1:500 1.0 ml
BSB 5245 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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