|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||ITGA2B encodes CD41, or integrin alpha IIb. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain IIb undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface medicated signalling.
CD41 expression has been found on platelets, megakaryocyes, and immature hematopoietic progenitors.
|Antibody Type||Rabbit Monoclonal||Clone||EP178|
|Localization||Membranous, Cytoplasmic||Control||Bone Marrow, Spleen|
|Presentation||CD41 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|