IHC of CD33 on a FFPE Colon Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

CD33 (gp62 or siglec-3) is a glycosylated transmembrane protein that is a member of the sialic acid-binding immunoglobulin-like lectin (siglec) family. The genomic locus of this protein has been mapped to chromosome 19q13.1-3.5. The function of CD33 is not known, but it may have a role in cell-to-cell adhesion. In maturing granulocytic cells, there is progressive down-regulation of CD33 from the blast stage to mature neutrophils. However, in monocytes and macrophages/histiocytes, strong expression of CD33 is maintained throughout maturation.

Detection of CD33 using monoclonal antibodies has been a critical component in immunophenotyping acute leukemias, particularly Acute Myeloid Leukemias.

Antibody Type Rabbit Monoclonal Clone RBT-CD33
Isotype IgG Reactivity Paraffin, Frozen
Localization Membranous Control Placenta, Myometrium, Lung, Colon, Spleen, Lymph Node, Tonsil, Acute Myeloid Leukemia
Presentation CD33 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 3448 Prediluted Ready-To-Use 3.0 ml
BSB 3449 Prediluted Ready-To-Use 7.0 ml
BSB 3450 Prediluted Ready-To-Use 15.0 ml
BSB 3451 Concentrated 1:10-1:50 0.1 ml
BSB 3452 Concentrated 1:10-1:50 0.5 ml
BSB 3453 Concentrated 1:10-1:50 1.0 ml
BSB 3454 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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