IHC of CD25 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCD25 is the alpha chain of the IL-2 receptor. It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2. Studies have shown that a large proportion of resting memory T cells constitutively express CD25. CD25 is expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, and tumor infiltrating lymphocytes. Its soluble form, called sIL-2R may be elevated in these diseases and is occasionally used to track disease progression. CD25 is also utilized in cases of mastocytosis
Antibody TypeRabbit MonoclonalCloneRBT-CD25
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlTonsil, Small Bowel, Spleen, Mastocytosis,Hodgkin’s Lymphoma
PresentationCD25 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2454PredilutedReady-To-Use3.0 ml
BSB 2455PredilutedReady-To-Use7.0 ml
BSB 2456PredilutedReady-To-Use15.0 ml
BSB 2457Concentrated1:10-1:500.1 ml
BSB 2458Concentrated1:10-1:500.5 ml
BSB 2459Concentrated1:10-1:501.0 ml
BSB 2460Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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