IHC of CD15 on an FFPE Hodgkin’s Lymphoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

CD15 is a phosphatidylinositol-anchored transmembrane protein found on neutrophils and which may be involved in phagocytosis. It is expressed in patients with Hodgkin’s Disease, some B-cell Chronic Lymphocytic Leukemias, Acute Lymphoblastic Leukemias, and most Acute Non-Lymphocytic Leukemias. It is also called Lewis x. A positive reaction for CD15 combined with a negative reaction for CD45 and other B and T-lineage markers provides support for Reed-Sternberg cells found in Hodgkin’s disease. Also, this antibody does not detect Mesotheliomas, making it a more frequently used antibody to distinguish Epithelial Mesothelioma from Adenocarcinoma.

Antibody Type Rabbit Monoclonal Clone EP273
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Tonsil, Lymph Node, Hodgkin’s Lymphoma
Presentation CD15 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2852 Prediluted Ready-To-Use 3.0 ml
BSB 2853 Prediluted Ready-To-Use 7.0 ml
BSB 2854 Prediluted Ready-To-Use 15.0 ml
BSB 2855 Concentrated 1:25-1:100 0.1 ml
BSB 2856 Concentrated 1:25-1:100 0.5 ml
BSB 2857 Concentrated 1:25-1:100 1.0 ml
BSB 2858 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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