CD123 - Kikuchi-Fujimoto

IHC of CD123 on an FFPE Kikuchi-Fujimoto Disease Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCD123 is α chain of the IL-3 receptor. This 60-70 kDa transmembrane protein, by itself, binds to IL-3 with rather low affinity. However, when associated with CD131 (common β chain), the protein binds to IL-3 with high affinity. The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes. The receptor belongs to the Type I cytokine-receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CDw131) subunit. The CD123 receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, and megakaryocytes.
Antibody TypeMouse MonoclonalCloneBSB-59
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlTonsil, Lymph Node, Kikuchi-Fujimoto Disease
PresentationCD123 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5323Tinto PredilutedReady-To-Use3.0 ml
BSB 5324Tinto PredilutedReady-To-Use7.0 ml
BSB 5325Tinto PredilutedReady-To-Use15.0 ml
BSB 5326Concentrated1:25-1:1000.1 ml
BSB 5327Concentrated1:25-1:1000.5 ml
BSB 5328Concentrated1:25-1:1001.0 ml
BSB 5329Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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