CD123 - Kikuchi-Fujimoto

IHC of CD123 on an FFPE Kikuchi-Fujimoto Disease Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation CD123 is α chain of the IL-3 receptor. This 60-70 kDa transmembrane protein, by itself, binds to IL-3 with rather low affinity. However, when associated with CD131 (common β chain), the protein binds to IL-3 with high affinity. The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes. The receptor belongs to the Type I cytokine-receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CDw131) subunit. The CD123 receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, and megakaryocytes.
Antibody Type Mouse Monoclonal Clone BSB-59
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Tonsil, Lymph Node, Kikuchi-Fujimoto Disease
Presentation CD123 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5323 Tinto Prediluted Ready-To-Use 3.0 ml
BSB 5324 Tinto Prediluted Ready-To-Use 7.0 ml
BSB 5325 Tinto Prediluted Ready-To-Use 15.0 ml
BSB 5326 Concentrated 1:25-1:100 0.1 ml
BSB 5327 Concentrated 1:25-1:100 0.5 ml
BSB 5328 Concentrated 1:25-1:100 1.0 ml
BSB 5329 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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