CD10 RMab

IHC of CD10 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation CD10, also known as neutral endopeptidase (NEP), Neprilysin, and common Acute Lymphoblastic Leukemia antigen (CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer’s Disease.
CD10 is a useful marker for the characterization of childhood Leukemia and B-cell Lymphomas. This antibody reacts with the antigens of Lymphoblastic, Burkitt’s, and Follicular Lymphomas, and Chronic Myelocytic Leukemia. Also, CD10 detects the antigen of glomerular epithelial cells and the brush border of the proximal tubules. This characteristic may be helpful in interpreting renal ontogenesis in conjunction with other markers. Other non-lymphoid cells that are reactive with CD10 are breast myoepithelial cells, bile canaliculi, neutrophils, a small population of bone marrow cells, fetal small intestine epithelium, and normal fibroblasts.
Antibody Type Rabbit Monoclonal Clone EP195
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Kidney, Tonsil, Lymph Node
Presentation CD10 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6429 Prediluted Ready-To-Use 3.0 ml
BSB 6430 Prediluted Ready-To-Use 7.0 ml
BSB 6431 Prediluted Ready-To-Use 15.0 ml
BSB 6432 Concentrated 1:10-1:50 0.1 ml
BSB 6433 Concentrated 1:10-1:50 0.5 ml
BSB 6434 Concentrated 1:10-1:50 1.0 ml
BSB 6435 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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