Calponin-MMab

IHC of Calponin on an FFPE Leiomyoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Calponin is a 34 kDa polypeptide that interacts with actin, tropomyosin, and calmodulin. It is involved in smooth-muscle contraction mechanisms and is restricted exclusively to smooth-muscle tissue. Calponin is a calcium-binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein kinase (which is dependent upon calcium binding to calmodulin) releases the calponin’s inhibition of the smooth-muscle ATPase. Calponin has been found to be useful in differentiating benign sclerosing lesions of the breast from Carcinoma. Calponin positivity has also been noted in Malignant Myoepithelioma and Pleomorphic Adenoma of Salivary Gland origin, as well as in Angiomatoid Malignant Fibrous Histiocytoma.
Antibody Type Mouse Monoclonal Clone BSB-20
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Appendix, Uterus, Breast Ducts, Leiomyoma, Prostate, Colon, Breast, Skin
Presentation Anti-Calponin (CALP-A6) is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5120 Prediluted Ready-To-Use 3.0 ml
BSB 5121 Prediluted Ready-To-Use 7.0 ml
BSB 5122 Prediluted Ready-To-Use 15.0 ml
BSB 5123 Concentrated 1:50-1:200 0.1 ml
BSB 5124 Concentrated 1:50-1:200 0.5 ml
BSB 5125 Concentrated 1:50-1:200 1.0 ml
BSB 5126 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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