IHC of Caldesmon on an FFPE Appendix Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation Caldesmon 1, also known as CALD1, is a human gene. Caldesmon is a calmodulin-binding protein. Like Calponin, Caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle. This gene encodes a Calmodulin and actin-binding protein that play an essential role in the regulation of smooth muscle and nonmuscle contraction. Two closely-related variants of human Caldesmon have been identified. The h-Caldesmon variant (120–150 kD) is predominantly expressed in smooth muscle, whereas I-Caldesmon (70–80 kD) is found in non-muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. Anti-Caldesmon recognizes only the h-Caldesmon variant. Anti-Caldesmon antibody labels smooth muscle and tumors of smooth muscle, myofibroblastic, and myoepithelial differentiation. Anti-Caldesmon has also been used to differenti-ate Epithelioid Mesothelioma from Serous Papillary Carcinoma of the ovary.
Antibody Type Mouse Monoclonal Clone BSB-19
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Appendix, Uterus, Leiomyoma
Presentation Anti-Caldesmon (CALD-31) is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6099 Prediluted Ready-To-Use 3.0 ml
BSB 6100 Prediluted Ready-To-Use 7.0 ml
BSB 6101 Prediluted Ready-To-Use 15.0 ml
BSB 6102 Concentrated 1:100-1:400 0.1 ml
BSB 6103 Concentrated 1:100-1:400 0.5 ml
BSB 6104 Concentrated 1:100-1:400 1.0 ml
BSB 6105 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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