Caldesmon-MMab

IHC of Caldesmon on an FFPE Appendix Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Caldesmon 1, also known as CALD1, is a human gene. Caldesmon is a calmodulin-binding protein. Like Calponin, Caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle. This gene encodes a Calmodulin and actin-binding protein that play an essential role in the regulation of smooth muscle and nonmuscle contraction. Two closely-related variants of human Caldesmon have been identified. The h-Caldesmon variant (120–150 kD) is predominantly expressed in smooth muscle, whereas I-Caldesmon (70–80 kD) is found in non-muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. Anti-Caldesmon recognizes only the h-Caldesmon variant. Anti-Caldesmon antibody labels smooth muscle and tumors of smooth muscle, myofibroblastic, and myoepithelial differentiation. Anti-Caldesmon has also been used to differenti-ate Epithelioid Mesothelioma from Serous Papillary Carcinoma of the ovary.
Antibody Type Mouse Monoclonal Clone BSB-19
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Appendix, Uterus, Leiomyoma
Presentation Anti-Caldesmon (CALD-31) is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6099 Prediluted Ready-To-Use 3.0 ml
BSB 6100 Prediluted Ready-To-Use 7.0 ml
BSB 6101 Prediluted Ready-To-Use 15.0 ml
BSB 6102 Concentrated 1:100-1:400 0.1 ml
BSB 6103 Concentrated 1:100-1:400 0.5 ml
BSB 6104 Concentrated 1:100-1:400 1.0 ml
BSB 6105 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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