IHC of C3d on a FFPE Rejected Kidney Transplant Tissue

IF of C3d on a Frozen Lupus Erythematosus Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.

This antibody is intended for use in Immunohistochemical (IHC) and Immunofluorescence (IF) applications on formalin-fixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by a qualified medical professional.

Summary and Explanation Complement component 3, or C3, is a protein of the immune system that plays a central role in the complement system and contributes to innate immunity. Its activation is required for both classical and alternative complement activation pathways. C3d deposition in the renal transplant PTCs (peritubular capillaries) is indicative of AR (acute rejection) with subsequent high probability of graft loss.

Anti-C3d combined with anti-C4d can be utilized as a tool for diagnosis of AR and warrant prompt and aggressive anti-rejection treatment. C3d is also a helpful adjunct in the diagnosis of bullous pemphigoid (BP) and perhaps pemphigus vulgaris (PV), especially in the cases in which only formalin-fixed, paraffin embedded

tissue is available for analysis.

Antibody Type Rabbit Polyclonal Clone Polyclonal
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Rejected Kidney Transplant
Presentation C3d is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6387 Prediluted Ready-To-Use* 3.0 ml
BSB 6388 Prediluted Ready-To-Use* 7.0 ml
BSB 6389 Prediluted Ready-To-Use* 15.0 ml
BSB 6390 Concentrated 1:100 / 1:500 0.1 ml
BSB 6391 Concentrated 1:100 / 1:500 0.5 ml
BSB 6392 Concentrated 1:100 / 1:500 1.0 ml
BSB 6393 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

*Ready-to-Use, for IHC only!