IHC of c-Myc on an FFPE Burkitt’s Lymphoma Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||Oncogene-encoded proteins c-Myc, n-Myc, and l-Myc function in cell proliferation, differentation and neoplastic disease. A mutated version of Myc is found in many cancers, which causes Myc to be constitutively expressed. This leads to the unregulated expression of many genes, some of which are involved in cell proliferation, and result in the formation of cancer. c-Myc is a transcription factor and is a proto-oncogene that is the focal point in cell cycle regulation, metabolism, apoptosis, differentiation, cell adhesion, and tumorigenesis.
A common human translocation involving Myc is t(8;14), which is criticial to the development of most cases of Burkitt’s Lymphoma. Malfunctions in Myc have also been found in carcinoma of the cervix, colon, breast, lung, and stomach.
|Antibody Type||Rabbit Monoclonal||Clone||EP121|
|Localization||Nuclear, Cytoplasmic||Control||Burkitt Lymphoma, Lung Cancer, Prostate Cancer|
|Presentation||c-Myc is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|