c-Myc RMab

IHC of c-Myc on an FFPE Burkitt’s Lymphoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Oncogene-encoded proteins c-Myc, n-Myc, and l-Myc function in cell proliferation, differentation and neoplastic disease. A mutated version of Myc is found in many cancers, which causes Myc to be constitutively expressed. This leads to the unregulated expression of many genes, some of which are involved in cell proliferation, and result in the formation of cancer. c-Myc is a transcription factor and is a proto-oncogene that is the focal point in cell cycle regulation, metabolism, apoptosis, differentiation, cell adhesion, and tumorigenesis.
A common human translocation involving Myc is t(8;14), which is criticial to the development of most cases of Burkitt’s Lymphoma. Malfunctions in Myc have also been found in carcinoma of the cervix, colon, breast, lung, and stomach.
Antibody Type Rabbit Monoclonal Clone EP121
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear, Cytoplasmic Control Burkitt Lymphoma, Lung Cancer, Prostate Cancer
Presentation c-Myc is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6576 Prediluted Ready-To-Use 3.0 ml
BSB 6577 Prediluted Ready-To-Use 7.0 ml
BSB 6578 Prediluted Ready-To-Use 15.0 ml
BSB 6579 Concentrated 1:10-1:50 0.1 ml
BSB 6580 Concentrated 1:10-1:50 0.5 ml
BSB 6581 Concentrated 1:10-1:50 1.0 ml
BSB 6582 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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