IHC of c-Met on an FFPE Papillary Thyroid Carcinoma Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation c-Met is a proto-oncogene that encodes hepatocyte growth factor receptor (HGFR). The HGFR protein possesses tyrosinase-kinase activity. MET is a membrane receptor that is essential for embryonic development and wound healing, with its only known ligand being hepatocyte growth factor (HGF). Met is normally expressed by cells of epithelial origin, while expression of HGF is restricted to cells of mesenchymal origin. Upon HGF stimulation, MET induces several biological responses that collectively give rise to a program known as invasive growth.
MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability to express MET, and thus become the cause of cancer persistence and spread to other sites in the body (metastasis).
Antibody Type Rabbit Monoclonal Clone EP1454Y
Isotype IgG Reactivity Paraffin, Frozen
Localization Membranous, Cytoplasmic Control

Breast, Tonsil, Cervix, Papillary Thyroid Carcinoma, Colon Carcinoma

Presentation c-Met is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6583 Prediluted Ready-To-Use 3.0 ml
BSB 6584 Prediluted Ready-To-Use 7.0 ml
BSB 6585 Prediluted Ready-To-Use 15.0 ml
BSB 6586 Concentrated 1:10-1:50 0.1 ml
BSB 6587 Concentrated 1:10-1:50 0.5 ml
BSB 6588 Concentrated 1:10-1:50 1.0 ml
BSB 6589 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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