IHC of Beta-Catenin on an FFPE Breast Fibromatosis Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||Beta-Catenin is a subunit of the Cadherin protein complex. Cadherins are a type of protein normally expressed on the surface of certain cells. Specifically, Beta-Cateinin is a 92 kDa protein normally found in the cytoplasm of the cell in the sub-membranous location. This protein is associated with E-Cadherin and may be essential for the function of E-Cadherin.
Mutations in the Beta-Catenin gene result in the nuclear accumulation of this protein. Nuclear accumulation of this protein has been demonstrated in Fibromatosis lesions of the breast and abdomen, and therefore is useful in differentiating this lesion from other spindle-cell lesions that may occur in these locations.
|Antibody Type||Rabbit Monoclonal||Clone||EP35|
|Localization||Nuclear, Cytoplasmic, Membranous||Control||Fibromatosis of the Breast and Abdomen, Breast, Abdomen, Colon, Testis, Pancreas|
|Presentation||Beta-Catenin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|