IHC of Bcl-6 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

bcl-6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein. Antibodies to this protein stain the germinal center cells in lymphoid follicles, follicular cells and interfollicular cells in Follicular Lymphoma, Diffuse Large B-Cell Lymphomas, Burkitt’s Lymphoma, and the majority of the Reed-Sternberg cells in Nodular Lymphocyte-Predominant Hodgkin’s Disease. bcl-6 is also useful in identifying neoplastic cells in cases of nodular Lymphocyte-Predominant Hodgkin’s Disease. In contrast, anti-bcl-6 rarely stains Mantle-Cell Lymphoma and MALT Lymphoma. bcl-6 expression is seen in approximately 45% of CD30+ Anaplastic Large-Cell Lymphomas but is consistently absent in other peripheral T-cell Lymphomas.

Antibody Type Rabbit Monoclonal Clone EP278
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Tonsil, Lymph Node, Thymus, Skin, Breast, Brain, Follicular Lymphoma
Presentation bcl6 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2817 Prediluted Ready-To-Use 3.0 ml
BSB 2818 Prediluted Ready-To-Use 7.0 ml
BSB 2819 Prediluted Ready-To-Use 15.0 ml
BSB 2820 Concentrated 1:25-1:100 0.1 ml
BSB 2821 Concentrated 1:25-1:100 0.5 ml
BSB 2822 Concentrated 1:25-1:100 1.0 ml
BSB 2823 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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