bcl-2-MMab

IHC of bcl-2 on an FFPE Follicular Lymphoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation bcl-2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of bcl-2, such as in the case of translocation of bcl-2 to Ig heavy-chain loci, is thought to be the cause of Follicular Lymphoma. Anti-bcl-2 has shown consistent negative reaction on reactive germinal centers and positive staining of neoplastic follicles in Follicular Lymphoma. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. This antibody may also be used in distinguishing between those Follicular Lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2-negative. Anti-bcl-2 has been used as a predictive biomarker for recurrence of Cancer of the Breast and Non-Small-Cell Carcinoma of the Lung.
Antibody Type Mouse Monoclonal Clone BSB-5 (BCL2/A4)
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Tonsil, Lymph Node
Presentation Anti-bcl-2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5071 Prediluted Ready-To-Use 3.0 ml
BSB 5072 Prediluted Ready-To-Use 7.0 ml
BSB 5073 Prediluted Ready-To-Use 15.0 ml
BSB 5074 Concentrated 1:50-1:200 0.1 ml
BSB 5075 Concentrated 1:50-1:200 0.5 ml
BSB 5076 Concentrated 1:50-1:200 1.0 ml
BSB 5077 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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