bcl10-40X-1MEA20-39 Tonsil

IHC of Bcl-10 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.
Summary and Explanation bcl-10 (also known as B-cell lymphoma/leukemia 10) is a 233 amino acid protein encoded by the BCL10 gene on Chromosome 1. The protein encoded by this gene contains a caspase recruitment domain , and has been shown to induce apoptosis and activate NF-kappaB. This protein is reported to interact with caspase recruitment domains (CARD) containing proteins including CARD9, 10, 11 and 14. These proteins function as upstream regulators in NF-kappaB signaling.Studies have shown that bcl-10 plays a critical role in the development of mucosa associated lymphoma tissue (MALT) lymphoma, and can be utilized in the classification of lymphomas. The antibody labels subpopulations of normal B and T cells. In MALT lymphomas with the t(1;14) translocation, the antibody strongly labeled the nuclei and cytoplasm, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.
Antibody Type Mouse Monoclonal Clone BSB-22
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Nuclear, Cytoplasmic Control Tonsil, Kidney, Cervix, bladder TCC, MALT Lymphomas
Presentation bcl-10 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2698 Prediluted Ready-To-Use 3.0 ml
BSB 2699 Prediluted Ready-To-Use 7.0 ml
BSB 2700 Prediluted Ready-To-Use 15.0 ml
BSB 2701 Concentrated 1:100-1:500 0.1 ml
BSB 2702 Concentrated 1:100-1:500 0.5 ml
BSB 2703 Concentrated 1:100-1:500 1.0 ml
BSB 2704 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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