Annexin A1

IHC of Annexin A1 on a FFPE Hairy Cell Leukemia Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation The protein Annexin A1 is encoded by the ANXA1 gene, which is upregulated in hairy cell leukemia. Annexin A1 inhibits the NF-kB signal transduction pathway (which is exploited by cancerous cells to proliferate and avoid apoptosis) by binding to the p65 subunit, and has been of interest for use as a potential anti-cancer drug. It may also contain tumor suppressive and protective characteristics, which have been evidenced by its ability to protect against DNA damage induced by heat in breast cancer cells.
Annexin A1 is strongly expressed on the cell membrane and occasionally in the cytoplasm of tumor cells in 97% of samples from patients with hairy cell leukemia. By contrast, B-cell lymphomas other than hairy cell leukemia are ANXA1 negative. Thus, ANXA1 is a molecule specific to hairy cell leukemia that can be used to differentiate this disease from other B-cell lymphomas.
Antibody Type Mouse Monoclonal Clone BSB-95
Isotype IgG2b Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Liver, Tonsil, Spleen, Tymus, Lung, Colon, Hairy Cell Leukemia
Presentation Annexin-A1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6359 Prediluted Ready-To-Use 3.0 ml
BSB 6360 Prediluted Ready-To-Use 7.0 ml
BSB 6361 Prediluted Ready-To-Use 15.0 ml
BSB 6362 Concentrated 1:100-1:500 0.1 ml
BSB 6363 Concentrated 1:100-1:500 0.5 ml
BSB 6364 Concentrated 1:100-1:500 1.0 ml
BSB 6365 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Related Products