A-1-Antitrypsin-40X-1WEL23-18-1 Tonsil

IHC of Alpha-1-Antitrypsin on a FFPE Bladder Tonsil Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation Alpha-1-Antitrypsin (A1AT) is a glycoprotein generally known as serum trypsin inhibitor. Alpha-1-Antitrypsin is also referred to as alpha-1 proteinase inhibitor (A1PI) because it is a serine protease inhibitor (serpin), inhibiting a wide variety of proteases. It protects tissues from enzymes of inflammatory cells, especially elastase, and has a reference range in blood of 1.5 – 3.5 gram/liter (in the U.S. the reference range is generally expressed as mg/dL or micromoles), but the concentration can rise many fold upon acute inflammation. In its absence, elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (Chronic Obstructive Pulmonary Disease) in adults and cirrhosis in adults or children. Alpha-1-Antitrypsin is considered to be very useful in the study of inherited AAT defi ciency, benign and Malignant Hepatic Tumors and Yolk-Sac Carcinomas. Positive staining for A-1-Antitrypsin may also be used in detection of benign and malignant lesions of a histiocytic nature. Sensitivity and specificity of the results have made this antibody a useful tool in the screening of patients with Cryptogenic Cirrhosis or other forms of liver disease with portal fibrosis of unknown etiology.
Antibody Type Rabbit Polyclonal Clone N/A
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Tonsil, Lymph Node
Presentation Alpha-1-Antitrypsin is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Special Note Concentrated Alpha-1-Antitrypsin antibody should be diluted to its working dilution in ImmunoDNA Background Blocker (Cat.# BSB 0103, BSB 0104, BSB 0105, BSB 0106 or BSB 0107)
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5008 Prediluted Ready-To-Use 3.0 ml
BSB 5009 Prediluted Ready-To-Use 7.0 ml
BSB 5010 Prediluted Ready-To-Use 15.0 ml
BSB 5011 Concentrated 1:250-1:1000 0.1 ml
BSB 5012 Concentrated 1:250-1:1000 0.5 ml
BSB 5013 Concentrated 1:250-1:1000 1.0 ml
BSB 5014 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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