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BIO SB Products and Technology for Molecular Pathology

Bio SB performs R&D, production, distribution and marketing of unique products for Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescent in situ hybridization (FISH), Chromogenic in situ hybridization (CISH), Liquid-Based Cytology (LBC) and Polymerase Chain Reaction (PCR) technologies that meet the highest international standards for applications in Molecular Pathology, Cancer Research, Microbiology, Immunology and Genetics. BIO SB manufactures and develops products in accordance with FDA QSR 21 CFR Part 820 cGMP and ISO 13485:2003 standards. These guidelines enable us to produce an IVD product that meets the highest in vitro diagnostic standards.

Date News Link
March 10th, 2015 Bio SB Announces 47 New IVD Rabbit & Mouse Monoclonal Antibodies PDF
March 2015 USCAP Boston, MA | Booth 1018 Events
November 2014 Bio SB at Central America Convention of Pathology Events
July 2014 $99 Mouse Mono. & $199 Rabbit Mono. Predilutes Link
June 2014 Micro-polymer Detection System Press Release Link
April 2014 ISH Probes highlighted in Pathology Outlines Link
March 2014 Hydrophilic Plus Slide USCAP Poster Presentation PDF
February 2014 Tissue and Infectious Disease Cell line Arrays PDF
In addition to providing its customers with equipment, reagents, and kits, Bio SB also provides training and continual assistance to new and existing laboratories. Bio SB’s skill and knowledge in Immunopathology, lmmunology and Molecular Biology offer the total solution for both cell and tissue staining.

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MDR-1 RMab – EP271 – Antibody

Inset: IHC of MDR-1 on an FFPE Adrenal TissueBack to Antibodies List

Intended Use For In Vitro Diagnostic Use.
Summary and Explanation P-glycoprotein 1, also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243), functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance phenomenon observed in human cancer cells following prolonged chemotherapy. The classic form of multiple drug resistance is associated with an increase in the MDR protein, but not in all cases. MDR-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug transport pump that transports a variety of drugs from the brain back into the blood.
MDR-1 is extensively distributed and expressed in the intestinal epithelium, hepatocytes, renal proximal tubular cells, adrenal gland and capillary endothelial cells comprising the blood-brain and blood-testis barrier.
Antibody Type Rabbit Monoclonal Clone EP271
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Skeletal Muscle, Kidney, Adrenal, Liver
Presentation MDR-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6898 Prediluted Ready-To-Use 3.0 ml
BSB 6899 Prediluted Ready-To-Use 7.0 ml
BSB 6900 Prediluted Ready-To-Use 15.0 ml
BSB 6901 Concentrated 1:50-1:200 0.1 ml
BSB 6902 Concentrated 1:50-1:200 0.5 ml
BSB 6903 Concentrated 1:50-1:200 1.0 ml
BSB 6904 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.