BIO SB Products and Technology for Molecular Pathology

Bio SB performs R&D, production, distribution and marketing of unique products for Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescent in situ hybridization (FISH), Chromogenic in situ hybridization (CISH), Liquid-Based Cytology (LBC) and Polymerase Chain Reaction (PCR) technologies that meet the highest international standards for applications in Molecular Pathology, Cancer Research, Microbiology, Immunology and Genetics. BIO SB manufactures and develops products in accordance with FDA QSR 21 CFR Part 820 cGMP and ISO 13485:2003 standards. These guidelines enable us to produce an IVD product that meets the highest in vitro diagnostic standards.
Date News Link
November 2015 WASPaLM, Cancun, Mexico Events
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April 2015 AACR Philadelphia, PA | Booth 1018 Events
March 10th, 2015 Bio SB Announces 47 New IVD Rabbit & Mouse Monoclonal Antibodies PDF
March 2015 USCAP Boston, MA | Booth 1018 Events
November 2014 Bio SB at Central America Convention of Pathology Events
July 2014 $99 Mouse Mono. & $199 Rabbit Mono. Predilutes Link
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In addition to providing its customers with equipment, reagents, and kits, Bio SB also provides training and continual assistance to new and existing laboratories. Bio SB’s skill and knowledge in Immunopathology, lmmunology and Molecular Biology offer the total solution for both cell and tissue staining.

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Cyclin D1 – EP 12 – Antibody

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Intended Use For In Vitro Diagnostic Use
Summary and Explanation Cyclins are a family of proteins involved in the progression of cells through the cell cycle. Cyclins form a complex with their partner, cyclin-dependent kinase (Cdk), which activates the latter’s protein kinase function. Cyclins are so named because they are produced or degraded as needed in order to drive the cell through the different stages of the cell cycle. When its concentrations in the cell are low, the cyclin detaches from the Cdk, inhibiting the enzyme’s activity, probably by causing a protein chain to block the enzymatic site.Cyclin D1 or PRAD-1 or bcl-1 is one of the key cell-cycle regulators, and functions in association with Cdk4 and/or Cdk6 by phosphorylating the Rb protein. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including Mantle Cell Lymphomas. Cyclin D1 has been found to be overexpressed in breast carcinoma.
Antibody Type Rabbit Monoclonal Clone EP 12
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Tonsil, Placenta, Brain, Cervix, Mantle Cell Lymphoma, Breast Carcinoma
Presentation Cyclin D1 is a rabbit monoclonal antibody derived from cell culture supernatant
that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5,
containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2468 Prediluted Ready-To-Use 3.0 ml
BSB 2469 Prediluted Ready-To-Use 7.0 ml
BSB 2470 Prediluted Ready-To-Use 15.0 ml
BSB 2471 Concentrated 1:100-1:500 0.1 ml
BSB 2472 Concentrated 1:100-1:500 0.5 ml
BSB 2473 Concentrated 1:100-1:500 1.0 ml
BSB 2474 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
* The Cytokeratin 17 antibody, clone EP98, has been manufactured using Epitomics RabMab® technology covered under Patent No.’s 5,675,063 and 7,402,409.