BIO SB Products and Technology for Molecular Pathology
Bio SB performs R&D, production, distribution and marketing of unique products for Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescent in situ hybridization (FISH), Chromogenic in situ hybridization (CISH), Liquid-Based Cytology (LBC) and Polymerase Chain Reaction (PCR) technologies that meet the highest international standards for applications in Molecular Pathology, Cancer Research, Microbiology, Immunology and Genetics. BIO SB manufactures and develops products in accordance with FDA QSR 21 CFR Part 820 cGMP and ISO 13485:2003 standards. These guidelines enable us to produce an IVD product that meets the highest in vitro diagnostic standards.
|March 10th, 2015||Bio SB Announces 47 New IVD Rabbit & Mouse Monoclonal Antibodies|
|March 2015||USCAP Boston, MA | Booth 1018||Events|
|November 2014||Bio SB at Central America Convention of Pathology||Events|
|July 2014||$99 Mouse Mono. & $199 Rabbit Mono. Predilutes||Link|
|June 2014||Micro-polymer Detection System Press Release||Link|
|April 2014||ISH Probes highlighted in Pathology Outlines||Link|
|March 2014||Hydrophilic Plus Slide USCAP Poster Presentation|
|February 2014||Tissue and Infectious Disease Cell line Arrays|
|Intended Use||For In Vitro Diagnostic Use.|
|Summary and Explanation||P-glycoprotein 1, also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243), functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance phenomenon observed in human cancer cells following prolonged chemotherapy. The classic form of multiple drug resistance is associated with an increase in the MDR protein, but not in all cases. MDR-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug transport pump that transports a variety of drugs from the brain back into the blood.
MDR-1 is extensively distributed and expressed in the intestinal epithelium, hepatocytes, renal proximal tubular cells, adrenal gland and capillary endothelial cells comprising the blood-brain and blood-testis barrier.
|Antibody Type||Rabbit Monoclonal||Clone||EP271|
|Localization||Cytoplasmic||Control||Skeletal Muscle, Kidney, Adrenal, Liver|
|Presentation||MDR-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|